● スタッフ
	教　授	澁谷　博孝	Hirotaka SHIBUYA	内線5252	E-mail
	助　手	北村　千浪	Chinami KITAMURA	内線5251	E-mail
	助　手	前原　昭次	Shoji MAEHARA	内線5251	E-mail

	● 主な研究課題
	1.	植物共生微生物による天然有機化合物の変換
		Biotransformation of Natural Products by Endophytic Microbes
	2.	植物共生微生物の有用物質生産
		Bioproduction of Useful Substances by Endophytic Microbes
	3.	熱帯薬用植物由来の創薬シーズ探索
		Search for Pharmaceutical Seeds from Tropical Medicinal Plants

	1. Biooxidation at C-4 of Flavans by Endophytic Microbe
	2. Biologically Active Bisanthraquinones Produced by Endophytic Microbe
	3. Biologically Active C18 and C16-Alkynic Fatty Acids

	● 最近の主要論文
	1.	Composition of the Endophytic Filamentous Fungi Isolated from the Tea Plant Camellia sinensis,
		A. Agusta, K. Ohashi, H. Shibuya, J. Nat. Med., 60, (2006) in press.
	2.	Bisanthraquinone Metabolites Produced by the Endophytic Fungus Diaporthe sp.,
		A. Agusta, K. Ohashi, H. Shibuya, Chem. Pharm. Bull., 54 (3), 579-582 (2006).
	3.	Stereoselective Oxidation at C-4 of Flavans by the Endophytic Fungus Diaporthe sp. Isolated from
		a Tea Plant, A. Agusta, S. Maehara, K. Ohashi, P. Simanjuntak, H. Shibuya, Chem. Pharm. Bull.,
		53 (12), 1565-1569 (2005).
	4.	Biooxidation of (+)-Catechin and (-)-Epicatechin into 3,4-Dihydroxyflavan Derivatives by the
		Endophytic Fungus Diaporthe sp. Isolated from a Tea Plant, H. Shibuya, A. Sgusta, K. Ohashi,
		S. Maehara, P.Simanjuntak, Chem. Pharm. Bull., 53 (7), 866-867 (2005)
	5.	Preparation and Cancer Cell Invasion Inhibitory Effects of C16-Alkynic Fatty Acids, K. Ohashi,
		H. Winarno, M. Mukai, H. Shibuya, Chem. Pharm. Bull., 51 (4), 463-466 (2003).
	6.	Indonesian Medicinal Plants. XXV. Cancer Cell Invasion Inhibitory Effects of Chemical Constituents
		in the Parasitic Plant Scurrula atropurpurea (Loranthaceae), K. Ohashi, H. Winarno, M. Mukai,
		M. Inoue, M. S. Prana, P. Simanjuntak, H. Shibuya, Chem. Pharm. Bull., 51 (3), 343-345 (2003).
	7.	Transformation of Cinchona Alkaloids into 1-N-Oxide Derivatives by Endophytic Xylaria sp. Isolated
		from Cinchona pubescens, H. Shibuya, C. Kitamura, S. Maehara, M. Nagahata, H. Winarno,
		P. Simanjuntak, Kim, Y. wataya, K. Ohashi, Chem. Pharm. Bull., 51 (1), 71-74 (2003).