Œ¤‹†“à—e

Ôú±‹³Žö

Šw—ð

1980”N3ŒŽ@‹ãB‘åŠw–òŠw•”»–ò‰»Šw‰È‘²‹Æ

1985”N3ŒŽ  ‹ãB‘åŠw‘åŠw‰@–òŠwŒ¤‹†‰È–òŠwêU”ŽŽm‰Û’ö

           –žŠú‘ÞŠw

1986”N3ŒŽ@–òŠw”ŽŽm

E—ð

1985”N4ŒŽ@•ŸŽR‘åŠwE–òŠw•”E•Žè@

1991”N4ŒŽ@•ŸŽR‘åŠwE–òŠw•”EuŽt@

1996”N4ŒŽ@•ŸŽR‘åŠwE–òŠw•”E•‹³Žö@

1998”N9ŒŽ`•½¬1999”N8ŒŽ@

           Johns Hopkins‘åŠwˆãŠw•”E‹qˆõ•‹³Žö

          iTom August‹³Žöj

2006”N4ŒŽ@•ŸŽR‘åŠwE–òŠw•”E‹³Žö

Œ¤‹†

ƒe[ƒ}

‚Pj×–E“ଊ튯‚Å‚ ‚郊ƒ\ƒ\[ƒ€‚Ì–Œ‚ð\¬‚·‚铜ƒ^ƒ“ƒpƒNŽ¿

   iLAMPj‚ÉŠÖ‚·‚錤‹†

 

‚QjƒŠƒ\ƒ\[ƒ€•W“IƒVƒOƒiƒ‹‚𓱓ü‚µ‚½ƒƒNƒ`ƒ“‚ÉŠÖ‚·‚éŠî‘bŒ¤‹†

 

Žå—v˜_•¶

@Akasaki K, Yamaguchi Y, Furuno K, Tsuji H. @Purification, some properties, and tissue distribution of a major lysosome-associated membrane glycoprotein (r-lamp-2) of rat liver. J. Biochem (Tokyo). ;110Šª@922-927 (1991)

 

@Akasaki K, Michihara A, Mibuka K, Fujiwara Y, Tsuji H. Biosynthetic transport of a major lysosomal membrane glycoprotein, lamp-1: convergence of biosynthetic and endocytic pathways occurs at three distinctive points. Exp. Cell Res. 220Šª464-473 (1995)

 

@Tabuchi N, Akasaki K, Tsuji H. Ile (476), a constituent of di-leucine-based motif of a major lysosomal membrane protein, LGP85/LIMP II, is important for its proper distribution in late endosomes and lysosomes. Biochem. Biophys. Res. Commun. ;295Šª@149-156 (2002)

 

@Akasaki K, Nakamura N, Tsukui N, Yokota S, Murata S, Katoh R, Michihara A, Tsuji H, Marques ET Jr, August JT. Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes.@Arch. Biochem. Biophys. 425:147-157 (2004).@

–{˜_•¶‚É‚ÍJohns Hopkins‘åŠwˆãŠw•”@Tom@AugustŒ¤‹†Žº‚Ƃ̋¤“¯Œ¤‹†¬‰Ê‚ð•ñ‚µ‚½B–{Œ¤‹†‚Ì‘gDõF‚̃f[ƒ^‚ÍArch. Biochem. Biophys. 425Šª‚Q†‚Ì•\ކ‚ÉÌ—p‚³‚ꂽB

 

@Arruda L.B., Sim D., Chikhlikar P.R., Maciel M. Jr, Akasaki K., August J.T., Marques E.T Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking pathways and prime T and B cell responses to a diverse repertoire of epitopes.,  J. Immunol., 177Šª, 2265-2275  (2006)

–{˜_•¶‚É‚ÍJohns Hopkins‘åŠwˆãŠw•”@Tom@August‹³Žö‚ÌŒ¤‹†Žº‚Ƃ̋¤“¯Œ¤‹†‚̬‰Ê‚ð•ñ‚µ‚½B

 

@Akasaki, K, Suenobu, M, Mukaida, M, Michihara, A, Wada I. COOH-Terminal isoleucine of lysosome-associated membrane protein-1 (LAMP-1) is optimal for its efficient targeting to dense secondary lysosomes. J. Biochem.   148Šª@669-679@(2010).@ –{˜_•¶‚ɂ͕Ÿ“‡Œ§—§ˆã‰È‘åŠw@˜a“c@ˆè•v@‹³Žö‚Ƃ̋¤“¯Œ¤‹†‚̬‰Ê‚ð•ñ‚µ‚½B@

Š‘®Šw‰ï

“ú–{–òŠw‰ï

“ú–{¶‰»Šw‰ïi•]‹cˆõj

Œ¤‹†“à—e

¶•¨‚ð\¬‚·‚éŠî–{’PˆÊ‚Å‚ ‚é×–E‚ɂͶ‘Ì–Œ‚ň͂܂ꂽזE¬ŠíН‚ª‘¶Ý‚·‚éB‚“™ŠwZ‚̶•¨‚Ì‹³‰È‘‚É‚à‹LÚ‚³‚ê‚Ä‚¢‚éuŠjvAuƒ~ƒgƒRƒ“ƒhƒŠƒAvAuƒSƒ‹ƒW‘ÌvAu—t—ΑÌv‚ª‘ã•\“I‚È×–E¬ŠíН‚Å‚ ‚éB×–E¬ŠíН‚ɂ͓Á’è‚Ì‹@”\‚ªŠ„‚èU‚ç‚ê‚Ä‚¢‚éB—Ⴆ‚ÎAƒ~ƒgƒRƒ“ƒhƒŠƒA‚Í×–E‚ª¶‚«‚Ä‚¢‚­‚½‚߂ɕK—v‚ȃGƒlƒ‹ƒM[iATPj‚ðì‚èo‚·‰»Šw”½‰ž‚ªW–ñ‚µ‚Ä‚¢‚éBƒŠƒ\ƒ\[ƒ€(lysosome)‚à×–E¬ŠíН‚Å‚ ‚éBulyso‰Á…•ª‰ð@some‘Üv‚̈Ӗ¡‚ª‚ ‚èA“ú–{Œê‚Å‚ÍƒŠƒ\ƒ\[ƒ€‚Íu…‰ð¬‘Ìv‚Æ‚æ‚΂ê‚éB‘܂̒†‚ɂ͑½”‚ÌŽ_«‰Á…•ª‰ðy‘f‚ªŠÜ‚Ü‚êAƒ^ƒ“ƒpƒNŽ¿A‘½“œ—ÞAŠjŽ_‚Ȃǂ̶‘Ì‚•ªŽq‚ð‚»‚ê‚¼‚ê‚ÌŬ‚̃p[ƒc‚ɂ܂ŕª‰ð‚·‚éBˆê•û‚ÅAƒŠƒ\ƒ\[ƒ€‚͉½‚Å‚à•ª‰ð‚·‚é‚킯‚ł͂Ȃ­A‘ŠŽè‚ðŒµ–§‚É”Fޝ‚µ‚Ä‚¢‚éB‚»‚Ì”Fޝ‚É‚ÍƒŠƒ\ƒ\[ƒ€–Œ‚̬•ª‚ªd—v‚Å‚ ‚éB

@–Ɖu‚É‚¨‚¢‚ÄƒŠƒ\ƒ\[ƒ€‚Íd—v‚È–ðŠ„‚ð‰Ê‚½‚µ‚Ä‚¢‚éB”’ŒŒ‹…‚̈êŽí‚Å‚ ‚éD’†‹…‚âƒ}ƒNƒƒtƒ@[ƒW‚ÍŠO—ˆ‚Ì”÷¶•¨‚ðHì—p‚É‚æ‚Á‚ÄŽE‚µ‚Ä‚¢‚éB‚±‚ÌÛAƒŠƒ\ƒ\[ƒ€‚ÌŽ_«‰Á…•ª‰ðy‘f‚Í”÷¶•¨‚̃^ƒ“ƒpƒNŽ¿‚⑽“œ—Þ‚Ì•ª‰ð‚ðs‚Á‚Ä‚¢‚éB‚Ü‚½AƒŠƒ“ƒp‹…‚É“G‚Ìî•ñ‚ð’m‚点‚éuRŒ´’ñަv‚Æ‚¢‚¤‰ß’ö‚ÉƒŠƒ\ƒ\[ƒ€‚ª[‚­ŠÖŒW‚µ‚Ä‚¢‚éB“–Œ¤‹†Žº‚Å‚ÍƒŠƒ\ƒ\[ƒ€‚Ì‘Ü‚É‘Š“–‚·‚郊ƒ\ƒ\[ƒ€–Œ‚É‘½—ʂ̊܂܂ê‚铜ƒ^ƒ“ƒpƒNŽ¿ilysosome-associated membrane protein: LAMPj‚Ì‹@”\AƒŠƒ\ƒ\[ƒ€‚Ö‚Ì ‹Ç݉»‹@\‚ÌŒ¤‹†‚ðs‚Á‚Ä‚¢‚éB

LAMP-1‚É‚æ‚é”x–E‚Ì‘gDõFi•\ކ‚ÉÌ—p‚³‚ꂽƒf[ƒ^‚̈ꕔjF‡UŒ^”x–Eã”ç×–E‚ƃ}ƒNƒƒtƒ@[ƒWi–îˆój‚ªƒŠƒ\ƒ\[ƒ€‚𑽂­ŠÜ‚ñ‚Å‚¨‚èA‚±‚ê‚ç‚Ì×–E‚ÌHì—p‚ª·‚ñ‚Å‚ ‚邱‚Æ‚ðŽ¦‚µ‚Ä‚¢‚éB

“dŽqŒ°”÷‹¾‚É‚æ‚èA”|—{ŠÌ×–E‚É‚¨‚¯‚éLAMP-1‚Ì‹ÇÝ‚ðŠm”F‚µ‚½FLAMP-1‚ͬ–E‚Ì–Œ‚Ì“à‘¤‚É‹­‚­õF‚³‚ê‚Ä‚¢‚éB¬–E‚ÍƒŠƒ\ƒ\[ƒ€‚Å‚ ‚邪A‚»‚ÌŒ`ó‚Í—lX‚Å‚ ‚èAƒŠƒ\ƒ\[ƒ€‚ÌŒ`󂪈ê’è‚łȂ¢‚±‚Æ‚ðŽ¦‚µ‚Ä‚¢‚éBBC‚Í–Ñ×’_ŠÇibile canaliculusj‚Å‚ ‚èAƒŠƒ\ƒ\[ƒ€‚ª‚»‚ÌŽü‚è‚ÉW‚Ü‚Á‚Ä‚¢‚éBƒŠƒ\ƒ\[ƒ€‚ÅÁ‰»‚³‚ꂽ•¨Ž¿‚ª–Ñ×’_ŠÇ‚É•úo‚³‚ê‚Ä‚¢‚é‚à‚̂ƌ©‚ç‚ê‚éB

iŽÊ^‚͌̌Öì_“ñæ¶‚æ‚è’ñ‹Ÿ‚³‚ꂽj

 

 

 

 

“¹Œ´

y‹³Žö

Šw—ð

1993”N3ŒŽ@•ŸŽR‘åŠw–òŠw•”¶•¨–òŠw‰È‘²‹Æ

1995”N3ŒŽ@•ŸŽR‘åŠw‘åŠw‰@–òŠwŒ¤‹†‰Èˆã—ÖòŠwêUCŽm‰Û’öC—¹

1998”N3ŒŽ  ‹ž“s‘åŠw‘åŠw‰@lŠÔEŠÂ‹«ŠwŒ¤‹†‰È•¶‰»E’nˆæŠÂ‹«ŠwêU

@@@@   ŒãŠú”ŽŽm‰Û’öC—¹

           ‹ž“s‘åŠw”ŽŽmilŠÔEŠÂ‹«Šwb34†j

E—ð

1998”N4ŒŽ@•ŸŽR‘åŠwE–òŠw•”E•Žè@

2003”N4ŒŽ@•ŸŽR‘åŠwE–òŠw•”EuŽt@

2011”N4ŒŽ@•ŸŽR‘åŠwE–òŠw•”Ey‹³Žö@

Š‘®Šw‰ï

“ú–{–òŠw‰ï

SHR“™Ž¾Š³ƒ‚ƒfƒ‹‹¤“¯Œ¤‹†‰ïi•]‹cˆõj

Ü

2003”N11ŒŽ@“ú–{–òŠw‰ï’†‘Žl‘Žx•”§—ãÜ

‹¤“¯Œ¤‹†

2009”N“x`2011”N“xFiŠ”jƒG[ƒUƒCEƒt[ƒhƒPƒ~ƒJƒ‹

Œ¤‹†

ƒe[ƒ}

‚PjƒRƒŒƒXƒeƒ[ƒ‹’ቺ‚É‚æ‚èˆø‚«‹N‚±‚³‚ê‚郊ƒ\ƒ\[ƒ}ƒ‹ƒGƒLƒ\ƒTƒCƒg[ƒVƒX‚Ì

@@ƒƒJƒjƒYƒ€‰ð–¾

 

‚QjƒgƒRƒgƒŠƒGƒm[ƒ‹‚Ì”ü”’Œø‰Ê‚ÉŠÖ‚·‚錤‹†

 

‚RjƒRƒŒƒXƒeƒ[ƒ‹‡¬Œo˜H‚̉ð–¾

 

‚Sj”]‘²’†”­¶‹@˜‚ÉŠÖ‚·‚錤‹†