福山大学薬学部

医薬品化学研究室
Department of Medicinal & Synthetic Chemistry
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２０００年〜

  1. The ability of gallate and pyrogallol moieties of catechins to inhibit P-glycoprotein function
    N. Sugihara, Y. Tsutsui, T. Tagashira, T. Choshi, S. Hibino, J. Kamishikiryou, K. Furuno, J. Functional Foods, 3, 293-304 (2011).

  2. IMPROVED SYNTHESIS OF THE NEW FURO[3,2-h]ISOQUINOLINE ALKALOIDS TMC-120B AND TMC-120A, AND THEIR INHIBITORY ACTIVITIES AGAINST IFN-γ AND IL-4 PRODUCTION
    T. Choshi, T. Kumemura, H. Fujioka, Y. Hieda, and S. Hibino, Heterocycles, in press.
  3. New Synthesis of Carbazole-1,4-quinone using a Tandem Ring-Closing Metathesis and Dehydrogenation Reaction Under Oxygen Atmosphere, and its Application to the Synthesis of Murrayaquinone A
    T. Nishiyama, T. Choshi, K. Kitano, and S. Hibino, Tetrahedron Lett., 52, 3872-3875 (2011).
  4. SYNTHETIC STUDIES ON NITROGEN-CONTAINING FUSED-HETEROCYCLIC COMPOUNDS BASED ON THERMAL ELECTROCYCLIC REACTIONS OF 6π-ELECTRON AND AZA 6π-ELECTRON SYSTEMS
    T. Choshi and S. Hibino, Heterocycles, 83, 1205-1239 (2011).
  5. A DIBENZOYLMETHANE DERIVATIVE PROTECTS H2O2-INDUCED CELL DEATH AND INHIBITS LIPOPOLYSACCHARIDE-INDUCED NO PRODUCTION IN CULTURED RAT ASTROCYTES
    K. Takano, K. Sugita, M. Moriyama, K. Hashida, S. Hibino, T. Choshi, R. Murakami, M. Yamada, H. Suzuki, O. Hori, Y. Nakamura, J. Neuroscience Research, 89, 955-965 (2011).
  6. Total Synthesis of Benzo[c]phenanthridine Alkaloids Based on a Microwave-Assisted Electrocyclic Reaction of the Aza 6π-Electron System, and Structural Revision of Broussonpapyrine
    Y. Ishihara, S. Azuma, T. Choshi, K. Kohno, K. Ono, H. Tsutsumi, T. Ishizu, S. Hibino, Tetrahedron, 67, 1320-1333 (2011).
  7. Efficacy of dibenzoylmethane derivatives in protecting against endoplasmic reticulum stress and inhibiting NF-kappa B on dextran sulfate sodium induced colitis in mice
    R. Murakami, M. Uchida, O. Hori, N. Matsuura, T. Choshi, S. Hibino, and M. Yamada, Biol. Pharm. Bull., 33, 2029-2032 (2010).
  8. Ameliorating effects of tropisetron on dopaminergic disruption of prepulse inhibition via the α7 nicotinic acetylcholine receptor in Wistar rats
    S. Kohnomi, K. Suemaru, M. Goda, T. Choshi, S. Hibino, H. Kawasaki, H. Araki, Brain Research., 1353, 152-158 (2010).
  9. A Novel Total Synthdesis of the Bioactive Poly-substituted Carbazole Alkaloid Carbazomadurin A
    Y. Hieda, T. Choshi, S. Kishida, H. Fujioka, and S. Hibino, Tetrahedron Lett., 51, 3593-3596 (2010).
  10. TOTAL SYNTHESIS OF BIOACTIVE INDOLO[3,2-j]PHENANTHRIDINE ALKALOID, CALOTHRIXIN B
    S. Tohyama, T. Choshi, K. Matsumoto, A. Yamabuki, Y. Hieda, J. Nobuhiro, and S. Hibino, Heterocycles, 82, 397-416(2010).
  11. Nuclear factor κB Inhibition by Dibenzoylmethane Derivatives
    N. Matsuura, R. Murakami, T. Katayama, S. Hibino, T. Choshi, and M. Yamada, J. Health Sci., 55, 311-313 (2009).
  12. Nicotinic Acetylcholine Receptors are Possible Therapeutic Targets for Schizophrenia
    S. Kohnomi, K. Suemaru, H. Kawasaki, T. Choshi, S. Hibino, and H. Araki, Yakugaku Zasshi, 129, 197-201 (2009).
  13. A new synthesis of the benzo[c]phenanthridines nornitidine, noravicine, and isodecarine, based on a microwave-assisted electrocyclic reaction of the aza 6π-electron system
    K. Kohno, S. Azuma, T. Choshi, J. Nobuhiro, and S. Hibino, Tetrahedron Lett., 50, 590-592 (2009).
  14. A new synthetic Route to the 1-Oxygenated Carbazole Alkaloids, Mukonine and Clausine E (Clauzoline I)
    S. Tohyama, T. Choshi, S. Azuma, H. Fujioka, and S. Hibino, Heterocycles, 79, 955-965 (2009).
  15. Progress toward the Total Synthesis of the Bioactive Calothrixins A and B
    T. Choshi, and S. Hibino, Heterocycles, 77, 85-97 (2009).
  16. Novel synthesis of the 2-azaanthraquinone alkaloid, scorpinone, based on two microwave-assisted pericyclic reactions
    T. Choshi, T. Kumemura, J. Nobuhiro, and S. Hibino, Tetrahedron Lett., 49, 3725-3728(2008).
  17. A carbazole derivative protects cells against endoplasmic reticulum (ER) stress and glutathione depletion
    H. Miura, K. Takano, Y. Kitao, S. Hibino, T. Choshi, R. Murakami, H. Suzuki, M. Yamada, S. Ogawa, and O. Hori, J. Pharmacol Sci., 108, 164-171 (2008).
  18. The Enantioselective Total Synthesis of a β-Carboline Alkaloid, (S)-(-)-Dichotomine C
    K. Omura, T. Choshi, S. Watanabe, Y. Satoh, J. Nobuhiro, and S. Hibino, Chem. Pharm. Bull., 56, 237-238(2008).
  19. Lipase-catalyzed Asymmetric Synthesis of Desprenyl-carquinostatin A and Descycloavandulyl-lavenduquinocin
    T. Choshi, Y. Uchida, Y. Kubota, J. Nobuhiro, M. Takeshita, T. Hatano, and S. Hibino, Chem. Pharm. Bull., 55, 1060-1064(2007).
  20. A Dibenzoylmethane (DBM) Derivative Protects Dopaminergic Neurons Against Both Oxidative Stress and Endoplamic Reticulum (ER) Stress
    K. Takano, Y. Kitao, Y. Tabata, H. Miura, K. Sato, K. Takuma, K. Yamada, S. Hibino, T. Choshi, M. Iinuma, H. Suzuki, R. Murakami, M. Yamada, S. Ogawa, O. Hori, Am. J. Physiol. Cell. Phisiol., 293, 1884-1894 (2007).
  21. Synthesis of Peptidomimetic Analogues of Echinocandins
    Chao-Mei, Ma, S. Takeda, S. Hibino, and M. Daneshtalab, Heterocycles, 68, 721-732 (2006).
  22. Synthesis of 6-Methylindole-4,7-quinone and Anti-tumor Activities of its Related Indolequinones
    J. Nobuhiro, M. Hirayama, T. Choshi, K. Kamoshita, S. Maruyama, Y. Sukenaga, T. Ishidu, H. Fujioka, and S. Hibino, Heterocycles, 70, 491-499 (2006).
  23. A Biomimetic Synthesis of the Indolo[3,2-j]phenanthridine Alkaloid, Calothrixin B
    A. Yamabuki, H. Fujinawa, T. Choshi, S. Tohyama, K. Matsumoto, K. Ohmura, J. Nobuhiro, and S. Hibino, Tetrahedron Lett., 47, 5859-5861 (2006).
  24. Synthesis and Anti-tumor Activity of a Fluorinated Analog of Medrooxyprogesterone Acetate (MPA), 9α-Fluoromedroxy- progesterone Acetate (FMPA)
    N. Murata, S. Fujimori, Y. Ichihara, Y. Sato, T. Yamaji, H. Tsuboi, M. Uchida, H. Suzuki, M. Yamada, T. Oikawa, H. Nemoto, J. Nobuhiro, T. Choshi, and S. Hibino, Chem. Pharm. Bull., 54, 1567-1570(2006).
  25. Suppression of Laser-induced Choriodal Neovascularization by Subconjunctival Injection of 9α-Fluoromedroxyprogesterone (FMPA), an Anti-angiogenic Agent, in Rats
    N. Murata, T. Yamaji, M. Uchida, H. Tsuboi, H. Suzuki, M. Yamada, T. Oikawa, H. J. Nobuhiro, T. Choshi, and S. Hibino, Biol. Pharm. Bull., 29, 2410-2414 (2006).
  26. A Highly Efficient Synthesis of Trisperidine Through a Construction of Tetrahydrophenanthridine Based on a Microwave-Assisted Thermal Electrocyclic Reaction of an Aza 6π-Electron System
    T. Kumemura, T. Choshi, A. J. Yukawa, A. Hirose, J. Nobuhiro, and S. Hibino, Heterocycles, 66, 87-90 (2005).
  27. Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats
    Y. Kawasaki, C. Jin, K. Suemaru, H. Kawasaki, K. Shibata, T. Choshi, S. Hibino, Y. Gomita, and H. Araki, British Journal of Pharmacology, 145, 751-757 (2005).
  28. A new total synthesis of an indolo[3,2-j]phenanthridine alkaloid calothrixin B
    S. Tohyama, T. Choshi, K. Matsumoto, A. Yamabuki, K. Ikegata, J. Nobuhiro, and S. Hibino, Tetrahedron Lett., 46, 5263-5264 (2005).
  29. Synthesis of the new furo[3,2-h]isoquinoline alkaloid, TMC-120B from Aspergillus ustus
    T. Kumemura, T. Choshi, A. Hirata, M. Sera, Y. Takahashi, J. Nobuhiro, and S. Hibino, Chem. Pharm. Bull., 53, 393-397 (2005).
  30. Synthesis of 5-methylindole-4,7-quinone through a new construction of the functionalized indole ring based on the allene-mediated electrocyclic reaction involving the pyrrole[b]-bond
    M. Hirayama, T. Choshi, T. Kumemura, S. Tohyama, J. Nobuhiro, and S. Hibino, Heterocycles, 63, 1765-1770 (2004).
  31. Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic α7 receptors
    K. Suemaru, K. Yasuda, K. Umeda, H. Araki, K. Shibata, T. Choshi, S. Hibino, and Y. Gomita, British Journal of Pharmacology, 142, 843-850 (2004).
  32. Syntheses of the antibiotic alkaloids renierone, mimocin, renierol, renierol acetate, renierol propionate, and 7-methoxy-1,6-dimethylisoquinoline-5,8-dione
    N. Kuwabara, H. Hayashi, N. Hiramatsu, T. Choshi, T. Kumemura, J. Nobuhiro, and S. Hibino, Tetrahedron, 60, 2943-2952 (2004).
  33. Possible involvement of induction of brain-derived neurotrophic factor in the neuroprotective effect of a 5-phenylpyrimidine derivative
    K. Matsutomo, K. Yamamoto, Y. Karasawa, N. Hino, A. Nakamura, M. Takahashi, H. Araki, S. Okuyama, T. Choshi, E. Sugino, S. Hibino, M. Yoshimoto, Biochem. Pharmcology, 66, 1016-1023 (2003).
  34. A Total Synthesis of A New Type of Furo[3,2-h]isoquinoline Alkaloid, TMC-120B
    T. Kumemura, T. Choshi, A. Hirata, M. Sera, Y. Takahashi, J. Nobuhiro, and S. Hibino, Heterocycles, 61, 13-17 (2003).
  35. The Absolute Configuration of (+)-Oxopropaline D by Theoretical Calculation of Specific　Rotation and Asymmetric Synthesis.
    T. Kuwada,. M. Fukui, T. Hata, T. Choshi, J. Nobuhiro, Y. Ono, and S. Hibino, Chem. Pharm. Bull., 51, 20-23 (2003).
  36. A New Deprotection Procedure for the N-Methoxymethyl Group of N-Methoxymethyl Heterocyclic Compounds.
    T. Kuwada, M. Fukui, M. Hirayama, J. Nobuhiro, T. Choshi, and S. Hibino, Heterocycles, 58, 325-332 (2002).
  37. A New Synthesis of 6-Substituted Pyrido[2,3-d]pyrimidines.
    T. Kuwada, K. Harada, J. Nobuhiro, T. Choshi, and Satoshi Hibino, Heterocycles, 57, 2081-2090 (2002).
  38. Simple Indole Alkaloids and Those with a Nonrearranged Monoterpenoid Unit
    S. Hibino and T. Choshi, Nat. Prod. Rep., 19, 1-35 (2002).
  39. Synthetic Studies of Mutagenic andCarcinogenic Heterocyclic Amines
    S. Hibino, T. Choshi, J. Nobuhiro, The Scientific Report of Japan Research Industrial Science, 77-83 (2002)
  40. Novel Syntheses of Murrayaquinone and Furostifoline Through 4-Oxygenated Carbazoles by Allene-Mediated Electrocyclic Reactions Starting from 2-Chloroindole-3-carbaldehyde.
    H. Hagiwara, T. Choshi, J. Nobuhiro, H. Fujimoto, and S. Hibino, Chem. Pharm. Bull., 49, 881-886 (2001).
  41. Total Syntheses of β-Carboline Alkaloids, (R)-(-)-Pyridindolol K1, (R)-(-)-Pyridindolol K2, and (R)-(-)-Pyridindolol.
    N. Kanekiyo, T. Kuwada, T. Choshi, J. Nobuhiro, and S. Hibino, J. Org. Chem. , 66, 8793-8798 (2001).
  42. Simple Indole Alkaloids and Those with a Nonrearranged Monoterpenoid Unit.
    S. Hibino and T. Choshi, Nat. Prod. Rep., 18, 66-87 (2001).
  43. The First Total Synthesis of (R)-(-)-Pyridindolol K2 and Its enantiomer.
    N. Kanekiyo, T. Choshi, T. Kuwada, E. Sugino, and S. Hibino, Heterocycles, 53, 1877-1880 (2000).
  44. A Novel Total Synthesis of Antibiotic Carbazole Alkaloid Carbazomycin G.
    H. Hagiwara, T. Choshi, H. Fujimoto, E. Sugino, and S. Hibino, Tetrahedron, 56, 5807-5811 (2000).
  45. Total Syntheses of Novel Cytocidal β-Carboline Alkaloids, Oxopropalines D and G.
    T. Choshi, T. Kuwada, M. Fukui, Y. Matsuya, E. Sugino, and S. Hibino, Chem. Pharm. Bull., 48, 108-113 (2000).
  46. Inhibition by 9α-fluoromedoroxyprogesterone acetate (FMPA) against mammary carcinoma induced by dimethylbenz[a]anthracene in rats and angiogenesis in the rabbit cornea - comparison with medroxyprogesterone acetate (MPA)
    M. Uchida, H. Tsuboi, T. Yamaji, N. Murata, T. Kohno, E. Sugino, S. Hibino, M. Shimamura, T. Oikawa, Cancer Lett., 154, 63-69 (2000).

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